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October 18, 2017


Wednesday, October 18, 2017

Biostatistics Help: Faculty, Staff, Pre-MD and Post Doc Walk-In Clinic
11:00 AM - 12:00 PM

Biostatistics consulting is available to all Johns Hopkins University faculty, staff, pre-MD and post docs conducting clinical and translational research. 11:00 AM – 12:00 PM Wolfe Street Building Room: E3142 Contact Information: Nita James |
[multiple] DMH Wednesday Noon Seminar - Alex McCourt, JD, MPH
12:15 PM - 1:00 PM

Bloomberg School of Public Health

DMH Wednesday Noon Seminar Series

Alex McCourt, JD, MPH
Doctoral student
Department of Health Policy and Management
Johns Hopkins Bloomberg School of Public Health

State Firearm Laws and Suicide: Implications of transfer and public carrying policies

Continuing discussion with students from 1 - 1:30 PM in HH188.
Faculty Candidate Series - Sr. Faculty Adolescent Health
12:15 PM - 1:20 PM

Bloomberg School of Public Health

Reenvisioning Adolescent Health Promotion:  Trauma, Resilience, and Opportunity

Elizabeth Miller, MD, PhD
Director, Division of Adolescent and Young Adult Medicine

Children’s Hospital of Pittsburgh of UPMC

Professor of Pediatrics, University of Pittsburgh School of Medicine

Contact Information
Deenah Darom


Roy Lederman “Hyper-Molecules” in Cryo-Electron Microscopy (cryo-EM)."
3:00 PM - 4:00 PM


Speaker: Roy Lederman,Princeton University Abstract: Cryo-EM is an imaging technology that is revolutionizing structural biology; the Nobel Prize in Chemistry 2017 was recently awarded to Jacques Dubochet, Joachim Frank and Richard Henderson “for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution". Cryo-electron microscopes produce a large number of very noisy two-dimensional projection images of individual frozen molecules. Unlike related tomography methods, such as computed tomography (CT), the viewing direction of each image is unknown. The unknown directions, together with extreme levels of noise and additional technical factors, make the determination of the structure of molecules challenging. Unlike other structure determination methods, such as x-ray crystallography and nuclear magnetic resonance (NMR), cryo-EM produces measurements of individual molecules and not ensembles of molecules. Therefore, cryo-EM could potentially be used to study mixtures of different conformations of molecules. While current algorithms have been very successful at analyzing homogeneous samples, and can recover some distinct conformations mixed in solutions, the determination of multiple conformations, and in particular, continuums of similar conformations (continuous heterogeneity), remains one of the open problems in cryo-EM. I will discuss the “hyper-molecules” approach to continuous heterogeneity, and the numerical tools and analysis methods that we are developing in order to recover such hyper-molecules.

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